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KMID : 0388120010100040392
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Journal of Korean Society for the Study of Obesity
2001 Volume.10 No. 4 p.392 ~ p.398
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Association of QTc Interval and Anthropometric Parameters
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Kim Sung-Soo
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Abstract
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Backgroud: Prolongation of the QT interval on the EKG represents delayed repolarization of the ventricular myocardium and is considered a precursor of malignant ventricular arrhythmias and sudden cardiac death in obesity. The aim of the current investigation was to determine the correlation of QTc interval and anthropometric parameters[waist circumference(WC, cm), waist-to-hip raio(WHR), weight and body mass index(BMI,kg/㎡)].
Method: The QTc interval and anthropometric parameters were assessed in healthy women(n=683) and men(n=595) in Korea. The QTc intervals were assessed in the nonobese group (BMI<25=543 in women, 433 in men) and obese group (25＜BMI≤30, n=131 in women, 162 in men) and the nonabdominal nonbese group(WC <80 cm in women, n=148, WC <90cm in men, n=534) and abdominal obese group (WC ≥80cm in women, n=148, WC≥90cm in men, n=534）
Results: QTc interval associated with WC, WHR, BMI and weight in healthy Korean women. QTc interval associated with age and WC in men. Multiple regression model including parameters related to QTc interval was run stepwise to assess independent contribution to QTc interval. In women, WC was only predictor of QTc interval(R(2)=0.022, p=0.022). In men, QTc interal was not correlated with WC, WHR, weight and BMI. In women, QTc interval in obese group(25＜BMI≤30, p=0.02) and abdominal obese group(WC ≥80cm in women, WC ≥90cm in men, p=0.01) was greater than nonobese group(BMI<25) and nonabdominal nonobese group, relatively. In men, QTc interval was not greater.
Conclusion: WC is positively correlated with QTc interval in healthy Korean women(BMI<30). In women, QTc interval are greater in obese group and abdominal obese group than nonobese group and nonabdominal nonobese group.
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KEYWORD
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QTc interval, Waist circumference and obesity
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